Medial Temporal Lobe Encephalitis associated to Chikungunya Virus Infection: A Case Report during First Epidemic in Americas

Abstract—Chikunguniya can be associated with encephalitis which is a rare complication of chikunguniya. Such a rare case was attended at National University Hospital (Hondura) in August 2015, which was studied in detail. A 64 years, Honduran patient was admitted during the convalescent period of an acute febrile illness with arthralgias one month prior.  Two weeks later, he developed a severe inability to form new memories disorientation to date and time; forgetting family member´s names and daily routines.  The patient exhibited spontaneous crying and sadness.  Premorbid cognitive, behavioral and functional abilities were normal. Patient was evaluated and investigated.  On investigation Chikungunya IgM antibodies were positive and on Brain MRI revealed predominantly right medial temporal lobe hyperintensities in Diffusion weighed images; also seen in FLAIR sequences. Patient was confirmed as Chikunguniya case associated with medial temporal lobe encephalitis. So it is suggested that patients presenting with a rapidly evolving amnestic syndrome after an acute febrile illness with polyarthralgias in an endemic region should be tested for the Chikungunya virus.  More cases must be described and studied, however, to better characterize this condition.

Keywords: Temporal Lobe, Encephalitis, Chikungunya.

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Medical Journal: Medial Temporal Lobe Encephalitis associated to Chikungunya Virus Infection: A Case Report during First Epidemic in Americas

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