Abstract— In this study, implantable polyethylene/fluorouracil waffles were additively manufactured by selective laser sintering using different laser energy densities. SEM-EDS revealed a porous morphology for both PE and PE/FU waffles. High dispersion of fluorouracil particles were observed in samples prepared under different conditions. The PE/FU waffles manufactured at 5W had the highest flexural modulus, probably due to better PE particle coalescence, higher sinter degree and the dispersion of FU particles in the co-continuous porous PE matrix. The PE/FU waffles showed an initial burst as well as a rapid drug released, which are desirable characteristics for cancer treatment. This profile provides a high initial concentration of the drug in the cancer cells and a subsequent controlled release sustaining levels of the chemotherapeutic agent in the region of the bone tumor.
Keywords— Polyethylene/fluorouracil, Implantable drug delivery, Cancer treatment, Selective laser sintering.
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